Autowaves in the model of avascular tumour growth

A. V. Kolobov; V. V. Gubernov; A. A. Polezhaev

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arXiv · 0705.2747

Autowaves in the model of avascular tumour growth

A. V. Kolobov·V. V. Gubernov·A. A. Polezhaev

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Abstract

A mathematical model of infiltrative tumour growth taking into account cell proliferation, death and motility is considered. The model is formulated in terms of local cell density and nutrient (oxygen) concentration. In the model the rate of cell death depends on the local nutrient level. Thus heterogeneous nutrient distribution in tissue affects tumour structure and development. The existence of automodel solutions is demonstrated and their properties are investigated. The results are compared to the properties of the Kolmogorov-Petrovskii-Piskunov and Fisher equations. Influence of the nutrient distribution on the autowave speed selection as well as on the relaxation to automodel solution is demonstrated. The model adequately describes the data, observed in experiments.

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A. V. Kolobov, V. V. Gubernov, A. A. Polezhaev. 2007-05-18. Autowaves in the model of avascular tumour growth. https://arxiv.org/abs/0705.2747

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