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arXiv · 0706.0418

Immune System -- Tumor Efficiency Rate as a new Oncological Index for Radiotherapy Treatment Optimization

O. Sotolongo-Grau·D. Rodriguez-Perez·J. A. Santos-Miranda·O. Sotolongo-Costa·J. C. Antoranz
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Abstract

A dynamical system model for tumor -- immune system interaction together with a method to mimic radiation therapy are proposed. A large population of virtual patients is simulated following an ideal radiation treatment. A characteristic parameter, the Immune System -- Tumor Efficiency Rate (ISTER), is introduced. ISTER dependence of treatment success and other features is studied. Statistical results allow us to give a patient classification scheme. Radiotherapy treatment biological effective dose (BED) is thus optimized based on the patient physical condition, following the ALARA (As Low As Reasonably Achievable) criterion.

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O. Sotolongo-Grau, D. Rodriguez-Perez, J. A. Santos-Miranda, O. Sotolongo-Costa, J. C. Antoranz. 2007-06-28. Immune System -- Tumor Efficiency Rate as a new Oncological Index for Radiotherapy Treatment Optimization. https://arxiv.org/abs/0706.0418

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