Control of poultry chicken malaria by surface functionalized amorphous nanosilica

Dipankar Seth; Nitai Debnath; Ayesha Rahman; Sunit Mukhopadhyaya; Inga Mewis; Christian Ulrichs; R. L. Bramhachary; Arunava Goswami

arXiv · 0707.2446

Control of poultry chicken malaria by surface functionalized amorphous nanosilica

Dipankar Seth·Nitai Debnath·Ayesha Rahman·Sunit Mukhopadhyaya·Inga Mewis·Christian Ulrichs·R. L. Bramhachary·Arunava Goswami

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Abstract

Surface modified amorphous nanoporous silica molecules with hydrophobic as well as hydrophilic character can be effectively used as therapeutic drug for combating chicken malaria in poultry industry. The amorphous nanosilica was developed by top-down approach using volcanic soil derived silica as source material. Amorphous silica has long been used as feed additive for poultry industry and considered to be safe for human consumption by WHO and USDA. The basic mechanism of action of these nanosilica molecules is mediated by the physical absorption of VLDL, serum triglycerides and other serum cholesterol components in the lipophilic nanopores of nanosilica. This reduces the supply of the host derived cholesterol, thus limiting the growth of the malarial parasite in vivo.

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Dipankar Seth, Nitai Debnath, Ayesha Rahman, Sunit Mukhopadhyaya, Inga Mewis, Christian Ulrichs, R. L. Bramhachary, Arunava Goswami. 2007-07-17. Control of poultry chicken malaria by surface functionalized amorphous nanosilica. https://arxiv.org/abs/0707.2446

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