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arXiv · 0708.1971

Nimesulide limits kainate-induced oxidative damage in the rat hippocampus

E. Candelario-Jalil·H. H. Ajamieh·S. Sam·G. Martinez·O. S. Leon
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Abstract

Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on kainate-induced in vivo oxidative damage in the rat hippocampus. A clinically relevant dose of nimesulide (6 mg/kg, i.p.) was administered three times following kainate application (9 mg/kg, i.p.). After 24 h of kainate administration, the drastic decrease in hippocampal glutathione content and the significant increase in lipid peroxidation were attenuated in nimesulide-treated rats, suggesting that the induction of cyclooxygenase-2 is involved in kainate-mediated free radicals formation.

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E. Candelario-Jalil, H. H. Ajamieh, S. Sam, G. Martinez, O. S. Leon. 2007-08-14. Nimesulide limits kainate-induced oxidative damage in the rat hippocampus. https://arxiv.org/abs/0708.1971

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