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arXiv · 0708.3181

Point Mutations Effects on Charge Transport Properties of the Tumor-Suppressor Gene p53

Chi-Tin Shih·Stephan Roche·Rudolf A. Römer
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Abstract

We report on a theoretical study of point mutations effects on charge transfer properties in the DNA sequence of the tumor-suppressor p53 gene. On the basis of effective single-strand or double-strand tight-binding models which simulate hole propagation along the DNA, a statistical analysis of charge transmission modulations associated with all possible point mutations is performed. We find that in contrast to non-cancerous mutations, mutation hotspots tend to result in significantly weaker {\em changes of transmission properties}. This suggests that charge transport could play a significant role for DNA-repairing deficiency yielding carcinogenesis.

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Chi-Tin Shih, Stephan Roche, Rudolf A. Römer. 2007-08-23. Point Mutations Effects on Charge Transport Properties of the Tumor-Suppressor Gene p53. https://doi.org/10.1103/physrevlett.100.018105

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