Reduction to the Simplest - The Complexity of Minimalistic Heteropolymer Models

Michael Bachmann; Wolfhard Janke

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arXiv · 0710.4353

Reduction to the Simplest - The Complexity of Minimalistic Heteropolymer Models

Michael Bachmann·Wolfhard Janke

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Abstract

Simple coarse-grained hydrophobic-polar models for heteropolymers as the lattice HP and the off-lattice AB model allow a general classification of characteristic behaviors for hydrophobic-core based tertiary folding. The strongly reduced computational efforts enable one to reveal systematically the thermodynamic properties of comparatively long sequences in a wide temperature range of conformational activity. Based on a suitable cooperativity parameter, characteristic folding channels and free-energy landscapes, which have strong similarities with realistic folding paths, can be analysed.

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Michael Bachmann, Wolfhard Janke. 2007-10-23. Reduction to the Simplest - The Complexity of Minimalistic Heteropolymer Models. https://arxiv.org/abs/0710.4353

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