Flow-correlated dilution of a regular network leads to a percolating network during tumor induced angiogenesis

Raja Paul

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arXiv · 0711.4498

Flow-correlated dilution of a regular network leads to a percolating network during tumor induced angiogenesis

Raja Paul

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Abstract

We study a simplified stochastic model for the vascularization of a growing tumor, incorporating the formation of new blood vessels at the tumor periphery as well as their regression in the tumor center. The resulting morphology of the tumor vasculature differs drastically from the original one. We demonstrate that the probabilistic vessel collapse has to be correlated with the blood shear force in order to yield percolating network structures. The resulting tumor vasculature displays fractal properties. Fractal dimension, microvascular density (MVD), blood flow and shear force has been computed for a wide range of parameters.

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Raja Paul. 2009-09-16. Flow-correlated dilution of a regular network leads to a percolating network during tumor induced angiogenesis. https://arxiv.org/abs/0711.4498

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