arXiv · 0712.1365
Population stratification using a statistical model on hypergraphs
Abstract
Population stratification is a problem encountered in several areas of biology and public health. We tackle this problem by mapping a population and its elements attributes into a hypergraph, a natural extension of the concept of graph or network to encode associations among any number of elements. On this hypergraph, we construct a statistical model reflecting our intuition about how the elements attributes can emerge from a postulated population structure. Finally, we introduce the concept of stratification representativeness as a mean to identify the simplest stratification already containing most of the information about the population structure. We demonstrate the power of this framework stratifying an animal and a human population based on phenotypic and genotypic properties, respectively.
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Alexei Vazquez. 2007-12-09. Population stratification using a statistical model on hypergraphs. https://doi.org/10.1103/physreve.77.066106
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