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arXiv · 0803.1261

Chance and necessity in chromosomal gene distributions

Rutger Hermsen·Pieter Rein ten Wolde·Sarah Teichmann
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Abstract

By analyzing the spacing of genes on chromosomes, we find that transcriptional and RNA-processing regulatory sequences outside coding regions leave footprints on the distribution of intergenic distances. Using analogies between genes on chromosomes and one-dimensional gases, we constructed a statistical null model. We have used this to estimate typical upstream and downstream regulatory sequence sizes in various species. Deviations from this model reveal bi-directional transcriptional regulatory regions in S. cerevisiae and bi-directional terminators in E. coli.

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Rutger Hermsen, Pieter Rein ten Wolde, Sarah Teichmann. 2008-03-08. Chance and necessity in chromosomal gene distributions. https://arxiv.org/abs/0803.1261

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