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arXiv · 0803.4415

Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics

Pierre-Emmanuel Morant·Quentin Thommen·François Lemaire·Constant Vandermoëre·Benjamin Parent·Marc Lefranc
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Abstract

We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable. We derive analytical criteria for the appearance of sustained oscillations and find that they require degradation mechanisms much less nonlinear than for infinitely fast regulation. Deterministic predictions are also compared with stochastic simulations of this minimal genetic oscillator.

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Pierre-Emmanuel Morant, Quentin Thommen, François Lemaire, Constant Vandermoëre, Benjamin Parent, Marc Lefranc. 2009-01-12. Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics. https://doi.org/10.1103/physrevlett.102.068104

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