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arXiv · 0807.3150

Stochastic model for nucleosome sliding in the presence of DNA ligands

Laleh Mollazadeh-Beidokhti·Julien Deseigne·David Lacoste·Farshid Mohammad-Rafiee·Helmut Schiessel
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Abstract

Heat-induced mobility of nucleosomes along DNA is an experimentally well-studied phenomenon. A recent experiment shows that the repositioning is modified in the presence of minor-groove binding DNA ligands. We present here a stochastic three-state model for the diffusion of a nucleosome along DNA in the presence of such ligands. It allows us to describe the dynamics and the steady state of such a motion analytically. The analytical results are in excellent agreement with numerical simulations of this stochastic process.With this model, we study the response of a nucleosome to an external force and how it is affected by the presence of ligands.

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Laleh Mollazadeh-Beidokhti, Julien Deseigne, David Lacoste, Farshid Mohammad-Rafiee, Helmut Schiessel. 2008-07-20. Stochastic model for nucleosome sliding in the presence of DNA ligands. https://doi.org/10.1103/physreve.79.031922

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