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arXiv · 0808.0630

Exact phase diagram of quasispecies model with mutation rate modifier

Apoorva Nagar·Kavita Jain
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Abstract

We consider an infinite asexual population with a mutator allele which can elevate mutation rates. With probability $f$, a transition from nonmutator to mutator state occurs but the reverse transition is forbidden. We find that at $f=0$, the population is in the state with minimum mutation rate and at $f=f_c$, a phase transition occurs between a mixed phase with both nonmutators and mutators and a pure mutator phase. We calculate the critical probability $f_c$ and the total mutator fraction $Q$ in the mixed phase exactly. Our predictions for $Q$ are in agreement with those seen in microbial populations in static environments.

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Apoorva Nagar, Kavita Jain. 2009-01-23. Exact phase diagram of quasispecies model with mutation rate modifier. https://doi.org/10.1103/physrevlett.102.038101

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