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arXiv · 0809.1729

Monte Carlo simulation for statistical mechanics model of ion channel cooperativity in cell membranes

Riza Erdem·Ekrem Aydiner
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Abstract

Voltage-gated ion channels are key molecules for the generation and propagation of electrical signals in excitable cell membranes. The voltage-dependent switching of these channels between conducting and nonconducting states is a major factor in controlling the transmembrane voltage. In this study, a statistical mechanics model of these molecules has been discussed on the basis of a two-dimensional spin model. A new Hamiltonian and a new Monte Carlo simulation algorithm are introduced to simulate such a model. It was shown that the results well match the experimental data obtained from batrachotoxin-modified sodium channels in the squid giant axon using the cut-open axon technique.

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BibTeXRIS

Riza Erdem, Ekrem Aydiner. 2008-12-22. Monte Carlo simulation for statistical mechanics model of ion channel cooperativity in cell membranes. https://doi.org/10.1103/physreve.79.031919

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