VE-cadherin and claudin-5: it takes two to tango

Julie Gavard; J Silvio Gutkind

doi:10.1038/ncb0808-883

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arXiv · 0811.4025

VE-cadherin and claudin-5: it takes two to tango

Julie Gavard·J Silvio Gutkind

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Abstract

Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively. Emerging evidence suggests that VE-cadherin controls claudin-5 expression by preventing the nuclear accumulation of FoxO1 and -catenin, which repress the claudin-5 promoter. This indicates that a crosstalk mechanism operates between these junctional structures.

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Julie Gavard, J Silvio Gutkind. 2008-11-25. VE-cadherin and claudin-5: it takes two to tango. https://doi.org/10.1038/ncb0808-883

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