Thermodynamics and dynamics of the formation of spherical lipidic vesicles

E. Hernandez Zapata; L. Martinez Balbuena; I Santamaria-Holek

doi:10.1016/j.bpj.2009.12.2617

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arXiv · 0905.4634

Thermodynamics and dynamics of the formation of spherical lipidic vesicles

E. Hernandez Zapata·L. Martinez Balbuena·I Santamaria-Holek

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Abstract

We propose a free energy expression accounting for the formation of spherical vesicles from planar lipidic membranes and derive a Fokker-Planck equation for the probability distribution describing the dynamics of vesicle formation. We found that formation may occur as an activated process for small membranes and as a transport process for sufficiently large membranes. We give explicit expressions for the transition rates and the characteristic time of vesicle formation in terms of the relevant physical parameters.

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E. Hernandez Zapata, L. Martinez Balbuena, I Santamaria-Holek. 2009-05-28. Thermodynamics and dynamics of the formation of spherical lipidic vesicles. https://doi.org/10.1016/j.bpj.2009.12.2617

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