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arXiv · 1003.0846

Cryptotomography: reconstructing 3D Fourier intensities from randomly oriented single-shot diffraction patterns

N. D. Loh·M. Bogan·V. Elser·A. Barty·S. Boutet·S. Bajt·J. Hajdu·T. Ekeberg·F. R. N. C. Maia·J. Schulz·M. M. Seibert·B. Iwan·N. Timneanu·S. Marchesini·I. Schlichting·R. L. Shoeman·L. Lomb·M. Frank·M. Liang·H. N. Chapman
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Abstract

We reconstructed the 3D Fourier intensity distribution of mono-disperse prolate nano-particles using single-shot 2D coherent diffraction patterns collected at DESY's FLASH facility when a bright, coherent, ultrafast X-ray pulse intercepted individual particles of random, unmeasured orientations. This first experimental demonstration of cryptotomography extended the Expansion-Maximization-Compression (EMC) framework to accommodate unmeasured fluctuations in photon fluence and loss of data due to saturation or background scatter. This work is an important step towards realizing single-shot diffraction imaging of single biomolecules.

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N. D. Loh, M. Bogan, V. Elser, A. Barty, S. Boutet, S. Bajt, J. Hajdu, T. Ekeberg, F. R. N. C. Maia, J. Schulz, M. M. Seibert, B. Iwan, N. Timneanu, S. Marchesini, I. Schlichting, R. L. Shoeman, L. Lomb, M. Frank, M. Liang, H. N. Chapman. 2010-04-06. Cryptotomography: reconstructing 3D Fourier intensities from randomly oriented single-shot diffraction patterns. https://doi.org/10.1103/physrevlett.104.225501

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