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arXiv · 1008.4025

Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery

Tamas Korcsmaros·Illes J. Farkas·Maté S. Szalay·Petra Rovo·David Fazekas·Zoltan Spiro·Csaba Bode·Katalin Lenti·Tibor Vellai·Peter Csermely
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Abstract

Motivation: Signaling pathways control a large variety of cellular processes. However, currently, even within the same database signaling pathways are often curated at different levels of detail. This makes comparative and cross-talk analyses difficult. Results: We present SignaLink, a database containing 8 major signaling pathways from Caenorhabditis elegans, Drosophila melanogaster, and humans. Based on 170 review and approx. 800 research articles, we have compiled pathways with semi-automatic searches and uniform, well-documented curation rules. We found that in humans any two of the 8 pathways can cross-talk. We quantified the possible tissue- and cancer-specific activity of cross-talks and found pathway-specific expression profiles. In addition, we identified 327 proteins relevant for drug target discovery. Conclusions: We provide a novel resource for comparative and cross-talk analyses of signaling pathways. The identified multi-pathway and tissue-specific cross-talks contribute to the understanding of the signaling complexity in health and disease and underscore its importance in network-based drug target selection. Availability: http://SignaLink.org

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Tamas Korcsmaros, Illes J. Farkas, Maté S. Szalay, Petra Rovo, David Fazekas, Zoltan Spiro, Csaba Bode, Katalin Lenti, Tibor Vellai, Peter Csermely. 2010-08-24. Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery. https://doi.org/10.1093/bioinformatics%2Fbtq310

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