How is the Monoclonal Antibodies Kinetic Affected by Changes of Their Physical Parameters?

Camilo Delgado-Correal; Carolina Daza; Heidy Alexandra Lizarazo-Pérez

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arXiv · 1009.4767

How is the Monoclonal Antibodies Kinetic Affected by Changes of Their Physical Parameters?

Camilo Delgado-Correal·Carolina Daza·Heidy Alexandra Lizarazo-Pérez

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Abstract

The study of monoclonal antibodies (MAb) is a field of great interest to science medicine, for example, anti-TNF agents (infliximab and adalimumab) represent an important tool for the management of autoimmune and inflammatory disorders. In this work we focus on the physical description of the transport kinetics of MAb in a fluid with laminar flow and parabolic profile. To simulate the kinetics of the MAb, standard equations were solved numerically (using The Verlet algorithm) to calculate the motion of a particle with a spherically symmetric inside of parabolic laminar flow, in order to find the time evolution of the antibody velocity in blood plasma in function of the increase of the radius, mass and density of the MAb, and the fluid pressure in blood vessels. In the case of we fixed the value of the antibody density, their kinetics increased when the pressure in the vessels increased. When we fixed the pressure in the vessels we found: if we reduce the antibody radius their kinetics increased, and when we increase antibody density we found that their kinetics also increased.

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Camilo Delgado-Correal, Carolina Daza, Heidy Alexandra Lizarazo-Pérez. 2010-09-24. How is the Monoclonal Antibodies Kinetic Affected by Changes of Their Physical Parameters?. https://arxiv.org/abs/1009.4767

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