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arXiv · 1010.4288

Modeling the Effects of Drug Binding on the Dynamic Instability of Microtubules

Peter Hinow·Vahid Rezania·Manu Lopus·Mary Ann Jordan·Jack A. Tuszynski
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Abstract

We propose a stochastic model that accounts for the growth, catastrophe and rescue processes of steady state microtubules assembled from MAP-free tubulin. Both experimentally and theoretically we study the perturbation of microtubule dynamic instability by S-methyl-D-DM1, a synthetic derivative of the microtubule-targeted agent maytansine and a potential anticancer agent. We find that to be an effective suppressor of microtubule dynamics a drug must primarily suppress the loss of GDP tubulin from the microtubule tip.

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Peter Hinow, Vahid Rezania, Manu Lopus, Mary Ann Jordan, Jack A. Tuszynski. 2011-07-14. Modeling the Effects of Drug Binding on the Dynamic Instability of Microtubules. https://doi.org/10.1088/1478-3975%2F8%2F5%2F056004

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