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arXiv · 1010.4459

A simplified exactly solvable model for beta-amyloid aggregation

Marco Zamparo·Antonio Trovato·Amos Maritan
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Abstract

We propose an exactly solvable simplified statistical mechanical model for the thermodynamics of beta-amyloid aggregation, generalizing a well-studied model for protein folding. The monomer concentration is explicitly taken into account as well as a non trivial dependence on the microscopic degrees of freedom of the single peptide chain, both in the alpha-helix folded isolated state and in the fibrillar one. The phase diagram of the model is studied and compared to the outcome of fibril formation experiments which is qualitatively reproduced.

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BibTeXRIS

Marco Zamparo, Antonio Trovato, Amos Maritan. 2010-10-21. A simplified exactly solvable model for beta-amyloid aggregation. https://doi.org/10.1103/physrevlett.105.108102

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