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arXiv · 1011.3151

Towards Biochemical Filter with Sigmoidal Response to pH Changes: Buffered Biocatalytic Signal Transduction

Marcos Pita·Vladimir Privman·Mary A. Arugula·Dmitriy Melnikov·Vera Bocharova·Evgeny Katz
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Abstract

We realize a biochemical filtering process by introducing a buffer in a biocatalytic signal-transduction logic system based on the function of an enzyme, esterase. The input, ethyl butyrate, is converted into butyric acid-the output signal, which in turn is measured by the drop in the pH value. The developed approach offers a versatile "network element" for increasing the complexity of biochemical information processing systems. Evaluation of an optimal regime for quality filtering is accomplished in the framework of a kinetic rate-equation model.

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Marcos Pita, Vladimir Privman, Mary A. Arugula, Dmitriy Melnikov, Vera Bocharova, Evgeny Katz. 2010-11-13. Towards Biochemical Filter with Sigmoidal Response to pH Changes: Buffered Biocatalytic Signal Transduction. https://doi.org/10.1039/c0cp02524k

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