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arXiv · 1101.0415

Collective response of self-organised clusters of mechanosensitive channels

Ksenia Guseva·Marco Thiel·Ian Booth·Samantha Miller·Celso Grebogi·Alessandro de Moura
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Abstract

Mechanosensitive channels are ion channels activated by membrane tension. We investigate the influence of bacterial mechanosensitive channels spatial distribution on activation (gating). Based on elastic short-range interactions we map this physical process onto an Ising-like model, which enables us to predict the clustering of channels and the effects of clustering on their gating. We conclude that the aggregation of channels and the consequent interactions among them leads to a global cooperative gating behaviour with potentially dramatic consequences for the cell.

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Ksenia Guseva, Marco Thiel, Ian Booth, Samantha Miller, Celso Grebogi, Alessandro de Moura. 2011-01-02. Collective response of self-organised clusters of mechanosensitive channels. https://doi.org/10.1103/physreve.83.020901

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