Low energy pathways for reproducible in vivo protein folding

Leonor Cruzeiro

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arXiv · 1101.0566

Low energy pathways for reproducible in vivo protein folding

Leonor Cruzeiro

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Abstract

Two proteins, one belonging to the mainly alpha class and the other belonging to the alpha/beta class, are selected to test a kinetic mechanism for protein folding. Targeted molecular dynamics is applied to generate folding pathways for those two proteins, starting from two well defined initial conformations: a fully extended and a alpha-helical conformation. The results show that for both proteins the alpha-helical initial conformation provides overall lower energy pathways to the native state. For the alpha/beta protein, 30 % (40%) of the pathways from an initial alpha-helix (fully extended) structure lead to unentangled native folds, a success rate that can be increased to 85 % by the introduction of a well-defined intermediate structure. These results open up a new direction in which to look for a solution to the protein folding problem, as detailed at the end.

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Leonor Cruzeiro. 2011-01-03. Low energy pathways for reproducible in vivo protein folding. https://arxiv.org/abs/1101.0566

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