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arXiv · 1103.4711

A Magnetically-Triggered Composite Membrane for On-Demand Drug Delivery

Todd Hoare·Jesus Santamaria·Gerardo F. Goya·Silvia Irusta·Debora Lin·Samantha Lau·Robert Padera·Robert Langer·Daniel S. Kohane
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Abstract

Nanocomposite membranes based on thermosensitive, poly(N-isopropylacrylamide)-based nanogels and magnetite nanoparticles have been designed to achieve "on-demand" drug delivery upon the application of an oscillating magnetic field. On-off release of sodium fluorescein over multiple magnetic cycles has been successfully demonstrated using prototype membrane-based devices. The total drug dose delivered was directly proportional to the duration of the "on" pulse. The membranes were non-cytotoxic, biocompatible, and retained their switchable flux properties after 45 days of subcutaneous implantation.

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Todd Hoare, Jesus Santamaria, Gerardo F. Goya, Silvia Irusta, Debora Lin, Samantha Lau, Robert Padera, Robert Langer, Daniel S. Kohane. 2011-03-24. A Magnetically-Triggered Composite Membrane for On-Demand Drug Delivery. https://arxiv.org/abs/1103.4711

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