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arXiv · 1105.0866

A Mathematical Model of Tripartite Synapse: Astrocyte Induced Synaptic Plasticity

Shivendra Tewari·Kaushik Majumdar
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Abstract

In this paper we present a biologically detailed mathematical model of tripartite synapses, where astrocytes modulate short-term synaptic plasticity. The model consists of a pre-synaptic bouton, a post-synaptic dendritic spine-head, a synaptic cleft and a peri-synaptic astrocyte controlling Ca2+ dynamics inside the synaptic bouton. This in turn controls glutamate release dynamics in the cleft. As a consequence of this, glutamate concentration in the cleft has been modeled, in which glutamate reuptake by astrocytes has also been incorporated. Finally, dendritic spine-head dynamics has been modeled. As an application, this model clearly shows synaptic potentiation in the hippocampal region, i.e., astrocyte Ca2+ mediates synaptic plasticity, which is in conformity with the majority of the recent findings (Perea & Araque, 2007; Henneberger et al., 2010; Navarrete et al., 2012).

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Shivendra Tewari, Kaushik Majumdar. 2011-05-04. A Mathematical Model of Tripartite Synapse: Astrocyte Induced Synaptic Plasticity. https://doi.org/10.1007/s10867-012-9267-7

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