Searcharxiv⌕ Search
Home/Archive/arXiv

arXiv · 1106.1578

Simplifying the Jacobian Criterion for precluding multistationarity in chemical reaction networks

Badal Joshi·Anne Shiu
View original source ↗Read source document ↗Export metadata ↓

Abstract

Chemical reaction networks taken with mass-action kinetics are dynamical systems that arise in chemical engineering and systems biology. In general, determining whether a chemical reaction network admits multiple steady states is difficult, as this requires determining existence of multiple positive solutions to a large system of polynomials with unknown coefficients. However, in certain cases, various easy criteria can be applied. One such test is the Jacobian Criterion, due to Craciun and Feinberg, which gives sufficient conditions for ruling out the possibility of multiple steady states. A chemical reaction network is said to pass the Jacobian Criterion if all terms in the determinant expansion of its parametrized Jacobian matrix have the same sign. In this article, we present a procedure which simplifies the application of the Jacobian Criterion, and as a result, we identify a new class of networks for which multiple steady states is precluded: those in which all chemical species have total molecularity of at most two. The total molecularity of a species refers to the sum of all of its stoichiometric coefficients in the network. We illustrate our results by examining enzyme catalysis networks.

Explore related subjects

math.DSq-bio.MN

Keep this discovery

BibTeXRIS

Badal Joshi, Anne Shiu. 2012-02-14. Simplifying the Jacobian Criterion for precluding multistationarity in chemical reaction networks. https://arxiv.org/abs/1106.1578

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Admissible Fourier Lengths, KAM Reducibility, and Spectral Applications

We develop a perturbative KAM reducibility theory for one-frequency $\mathrm{SL}(2,\mathbb{R})$ cocycles based on an admissible Fourier length $\ell$. The regularity relevant to the iteration is measured by positive adapted Fourier width rather than ordinary smoothness in the Euclidean length $|n|$. The same length governs Fourier decay, truncation and resonance scales, and the arithmetic condition controlling the small divisors. This framework contains the classical analytic and Gevrey settings, while non-monotone choices of $\ell$ allow classical nowhere differentiable Weierstrass-type perturbations and continuous perturbations outside every positive H\"older class. As spectral applications, we obtain purely absolutely continuous spectrum for every phase and $1/2$-H\"older continuity of the integrated density of states for the associated quasiperiodic Schr\"odinger operators. The Aubry dual has pure point spectrum for Lebesgue almost every dual phase, with eigenfunctions exponentially localized in the metric induced by $\ell$. We also construct nowhere differentiable quasiperiodic potentials with purely absolutely continuous Cantor spectrum.

math.DS↗
arXiv2026

Dynamics inside the attracting basins of some skew products

Polynomial skew products in $\mathbb{C}^2$ are maps of the form $F(z,w)=(P(z),Q(z,w))$, where $P$ and $Q$ are polynomials. Their local dynamics have been widely investigated. In this paper, we study the global dynamics inside Fatou components of some skew products. We consider all the inverse images in a Fatou component of a given point and use the Kobayashi metric to measure the distance between points. In the cases we consider, there are always arbitrarily large Kobayashi balls in the complement of these inverse sets.

math.DS↗
arXiv2026

Ergodicity of dynamical systems without uniqueness of orbits

Recently, there has been considerable interest in the study of non-deterministic dynamical systems. To analyze the chaotic behavior of such systems from a measure-theoretic viewpoint, it is desirable to consider ergodicity. However, the classical definition of ergodicity involves invariant sets, whose definition is not unique for non-deterministic dynamical systems. Thus, we are led to the question of which invariance yields an interesting definition of ergodicity. Here, we propose a definition based on the strong backward invariance and show that analogs of classical results hold. We also consider implications of the Birkhoff ergodic theorem for systems without uniqueness of orbits.

math.DS↗