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arXiv · 1106.6185

Effects of Compensation, Connectivity and Tau in a Computational Model of Alzheimer's Disease

Mark Rowan
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Abstract

This work updates an existing, simplistic computational model of Alzheimer's Disease (AD) to investigate the behaviour of synaptic compensatory mechanisms in neural networks with small-world connectivity, and varying methods of calculating compensation. It additionally introduces a method for simulating tau neurofibrillary pathology, resulting in a more dramatic damage profile. Small-world connectivity is shown to have contrasting effects on capacity, retrieval time, and robustness to damage, whilst the use of more easily-obtained remote memories rather than recent memories for synaptic compensation is found to lead to rapid network damage.

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Mark Rowan. 2011-06-30. Effects of Compensation, Connectivity and Tau in a Computational Model of Alzheimer's Disease. https://arxiv.org/abs/1106.6185

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