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arXiv · 1108.2395

The role of the coating and aggregation state in the interactions between iron oxide nanoparticles and 3T3 fibroblasts

Malak Safi·Jean-François Berret
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Abstract

Recent nanotoxicity studies revealed that the physico-chemical characteristics of engineered nanomaterials play an important role in the interactions with living cells. Here, we report on the toxicity and uptake of the iron oxide sub-10 nm nanoparticles by NIH/3T3 mouse fibroblasts. Coating strategies include low-molecular weight ligands (citric acid) and polymers (poly(acrylic acid), MW = 2000 g mol-1). We find that most particles were biocompatible, as exposed cells remained 100% viable relative to controls. The strong uptake shown by the citrate-coated particles is related to the destabilization of the dispersions in the cell culture medium and their sedimentation down to the cell membranes.

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Malak Safi, Jean-François Berret. 2011-08-10. The role of the coating and aggregation state in the interactions between iron oxide nanoparticles and 3T3 fibroblasts. https://doi.org/10.1016/j.phpro.2010.11.059

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