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arXiv · 1201.2961

Orientational correlations in confined DNA

E. Werner·F. Persson·F. Westerlund·J. O. Tegenfeldt·B. Mehlig
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Abstract

We study how the orientational correlations of DNA confined to nanochannels depend on the channel diameter D by means of Monte Carlo simulations and a mean-field theory. This theory describes DNA conformations in the experimentally relevant regime where the Flory-de Gennes theory does not apply. We show how local correlations determine the dependence of the end-to-end distance of the DNA molecule upon D. Tapered nanochannels provide the necessary resolution in D to study experimentally how the extension of confined DNA molecules depends upon D. Our experimental and theoretical results are in qualitative agreement.

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E. Werner, F. Persson, F. Westerlund, J. O. Tegenfeldt, B. Mehlig. 2012-10-05. Orientational correlations in confined DNA. https://doi.org/10.1103/physreve.86.041802

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