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arXiv · 1202.1940

Optimal control of cell mass and maturity in a model of follicular ovulation

Frédérique Clément·Jean-Michel Coron·Peipei Shang
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Abstract

In this paper, we study optimal control problems associated with a scalar hyperbolic conservation law modeling the development of ovarian follicles. Changes in the age and maturity of follicular cells are described by a 2D conservation law, where the control terms act on the velocities. The control problem consists in optimizing the follicular cell resources so that the follicular maturity reaches a maximal value in fixed time. Formulating the optimal control problem within a hybrid framework, we prove necessary optimality conditions in the form of Hybrid Maximum Principle. Then we derive the optimal strategy and show that there exists at least one optimal bang-bang control with one single switching time.

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Frédérique Clément, Jean-Michel Coron, Peipei Shang. 2012-10-15. Optimal control of cell mass and maturity in a model of follicular ovulation. https://doi.org/10.1137/120862247

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