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arXiv · 1204.6140

BioFET-SIM Web Interface: Implementation and Two Applications

Martin R. Hediger·Jan H. Jensen·Luca De Vico
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Abstract

We present a web interface for the BioFET-SIM program. The web interface allows to conveniently setup calculations based on the BioFET-SIM multiple charges model. As an illustration, two case studies are presented. In the first case, a generic peptide with opposite charges on both ends is inverted in orientation on a semiconducting nanowire surface leading to a corresponding change in sign of the computed sensitivity of the device. In the second case, the binding of an antibody/antigen complex on the nanowire surface is studied in terms of orientation and analyte/nanowire surface distance. We demonstrate how the BioFET-SIM web interface can aid in the understanding of experimental data and postulate alternative ways of antibody/antigen orientation on the nanowire surface.

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Martin R. Hediger, Jan H. Jensen, Luca De Vico. 2012-07-31. BioFET-SIM Web Interface: Implementation and Two Applications. https://doi.org/10.1371/journal.pone.0045379

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