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arXiv · 1206.0324

What does the Allen Gene Expression Atlas tell us about mouse brain evolution?

Swagatam Mukhopadhyay·Pascal Grange·Anirvan M. Sengupta·Partha P. Mitra
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Abstract

We use the Allen Gene Expression Atlas (AGEA) and the OMA ortholog dataset to investigate the evolution of mouse-brain neuroanatomy from the standpoint of the molecular evolution of brain-specific genes. For each such gene, using the phylogenetic tree for all fully sequenced species and the presence of orthologs of the gene in these species, we construct and assign a discrete measure of evolutionary age. The gene expression profile of all gene of similar age, relative to the average gene expression profile, distinguish regions of the brain that are over-represented in the corresponding evolutionary timescale. We argue that the conclusions one can draw on evolution of twelve major brain regions from such a molecular level analysis supplements existing knowledge of mouse brain evolution and introduces new quantitative tools, especially for comparative studies, when AGEA-like data sets for other species become available. Using the functional role of the genes representational of a certain evolutionary timescale and brain region we compare and contrast, wherever possible, our observations with existing knowledge in evolutionary neuroanatomy.

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Swagatam Mukhopadhyay, Pascal Grange, Anirvan M. Sengupta, Partha P. Mitra. 2012-06-01. What does the Allen Gene Expression Atlas tell us about mouse brain evolution?. https://arxiv.org/abs/1206.0324

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