Non-Gaussian dynamics of a tumor growth system with immunization

Mengli Hao; Ting Gao; Jinqiao Duan; Wei Xu

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arXiv · 1207.5890

Non-Gaussian dynamics of a tumor growth system with immunization

Mengli Hao·Ting Gao·Jinqiao Duan·Wei Xu

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Abstract

This paper is devoted to exploring the effects of non-Gaussian fluctuations on dynamical evolution of a tumor growth model with immunization, subject to non-Gaussian α-stable type Lévy noise. The corresponding deterministic model has two meaningful states which represent the state of tumor extinction and the state of stable tumor, respectively. To characterize the lifetime for different initial densities of tumor cells staying in the domain between these two states and the likelihood of crossing this domain, the mean exit time and the escape probability are quantified by numerically solving differential integral equations with appropriate exterior boundary conditions. The relationships between the dynamical properties and the noise parameters are examined. It is found that in the different stages of tumor, the noise parameters have different influence on the lifetime and the likelihood inducing tumor extinction. These results are relevant for determining efficient therapeutic regimes to induce the extinction of tumor cells.

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Mengli Hao, Ting Gao, Jinqiao Duan, Wei Xu. 2012-07-25. Non-Gaussian dynamics of a tumor growth system with immunization. https://arxiv.org/abs/1207.5890

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