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arXiv · 1208.3228

Model of the Human Sleep Wake System

Lisa Rogers·Mark Holmes
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Abstract

A model and analysis of the human sleep/wake system is presented. The model is derived using the known neuronal groups, and their various projections, involved with sleep and wake. Inherent in the derivation is the existence of a slow time scale associated with homeostatic regulation, and a faster time scale associated with the dynamics within the sleep phase. A significant feature of the model is that it does not contain a periodic forcing term, common in other models, reflecting the fact that sleep/wake is not dependent upon a diurnal stimulus. Once derived, the model is analyzed using a linearized stability analysis. We then use experimental data from normal sleep-wake systems and orexin knockout systems to verify the physiological validity of the equations.

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Lisa Rogers, Mark Holmes. 2012-08-15. Model of the Human Sleep Wake System. https://arxiv.org/abs/1208.3228

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