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arXiv · 1210.4630

Semiparametric Relative-risk Regression for Infectious Disease Data

Eben Kenah
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Abstract

This paper introduces semiparametric relative-risk regression models for infectious disease data based on contact intervals, where the contact interval from person i to person j is the time between the onset of infectiousness in i and infectious contact from i to j. The hazard of infectious contact from i to j is \lambda_0(\tau)r(\beta_0^T X_{ij}), where \lambda_0(\tau) is an unspecified baseline hazard function, r is a relative risk function, \beta_0 is an unknown covariate vector, and X_{ij} is a covariate vector. When who-infects-whom is observed, the Cox partial likelihood is a profile likelihood for \beta maximized over all possible \lambda_0(\tau). When who-infects-whom is not observed, we use an EM algorithm to maximize the profile likelihood for \beta integrated over all possible combinations of who-infected-whom. This extends the most important class of regression models in survival analysis to infectious disease epidemiology.

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Eben Kenah. 2012-10-17. Semiparametric Relative-risk Regression for Infectious Disease Data. https://doi.org/10.1080/01621459.2014.896807

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