Accelerated Time-of-Flight Mass Spectrometry

Morteza Ibrahimi; Andrea Montanari; George S Moore

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arXiv · 1212.4269

Accelerated Time-of-Flight Mass Spectrometry

Morteza Ibrahimi·Andrea Montanari·George S Moore

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Abstract

We study a simple modification to the conventional time of flight mass spectrometry (TOFMS) where a \emph{variable} and (pseudo)-\emph{random} pulsing rate is used which allows for traces from different pulses to overlap. This modification requires little alteration to the currently employed hardware. However, it requires a reconstruction method to recover the spectrum from highly aliased traces. We propose and demonstrate an efficient algorithm that can process massive TOFMS data using computational resources that can be considered modest with today's standards. This approach can be used to improve duty cycle, speed, and mass resolving power of TOFMS at the same time. We expect this to extend the applicability of TOFMS to new domains.

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Morteza Ibrahimi, Andrea Montanari, George S Moore. 2013-07-28. Accelerated Time-of-Flight Mass Spectrometry. https://arxiv.org/abs/1212.4269

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