Negative-feedback self-regulation contributes to robust and high-fidelity transmembrane signal transduction

M. Ángeles Serrano; Manuel Jurado; Ramon Reigada

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arXiv · 1212.4745

Negative-feedback self-regulation contributes to robust and high-fidelity transmembrane signal transduction

M. Ángeles Serrano·Manuel Jurado·Ramon Reigada

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Abstract

We present a minimal motif model for transmembrane cell signaling. The model assumes signaling events taking place in spatially distributed nanoclusters regulated by a birth/death dynamics. The combination of these spatio-temporal aspects can be modulated to provide a robust and high-fidelity response behavior without invoking sophisticated modeling of the signaling process as a sequence of cascade reactions and fine-tuned parameters. Our results show that the fact that the distributed signaling events take place in nanoclusters with a finite lifetime regulated by local production is sufficient to obtain a robust and high-fidelity response.

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M. Ángeles Serrano, Manuel Jurado, Ramon Reigada. 2013-04-20. Negative-feedback self-regulation contributes to robust and high-fidelity transmembrane signal transduction. https://arxiv.org/abs/1212.4745

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