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arXiv · 1305.3043

A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues

B. Werner·D. Dingli·A. Traulsen
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Abstract

We model a general, hierarchically organized tissue by a multi compartment approach, allowing any number of mutations within a cell. We derive closed solutions for the deterministic clonal dynamics and the reproductive capacity of single clones. Our results hold for the average dynamics in a hierarchical tissue characterized by an arbitrary combination of proliferation parameters.

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B. Werner, D. Dingli, A. Traulsen. 2013-05-14. A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues. https://arxiv.org/abs/1305.3043

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