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arXiv · 1305.5223

Sensitive Chiral Analysis via Microwave Three-wave Mixing

David Patterson·John M. Doyle
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Abstract

We demonstrate chirality-induced three-wave mixing in the microwave regime, using rotational transitions in cold gas-phase samples of 1,2-propanediol and 1,3-butanediol. We show that bulk three-wave mixing, which can only be realized in a chiral environment, provides a sensitive, species selective probe of enantiomeric excess and is applicable to a broad class of molecules. The doubly resonant condition provides simultaneous identification of species and of handedness, which should allow sensitive chiral analysis even within a complex mixture.

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David Patterson, John M. Doyle. 2013-05-22. Sensitive Chiral Analysis via Microwave Three-wave Mixing. https://doi.org/10.1103/physrevlett.111.023008

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