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arXiv · 1305.6246

Controlling light in scattering media noninvasively using the photo-acoustic transmission-matrix

T. Chaigne·O. Katz·A. C. Boccara·M. Fink·E. Bossy·S. Gigan
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Abstract

Optical wavefront-shaping has emerged as a powerful tool to manipulate light in strongly scattering media. It enables diffraction-limited focusing and imaging at depths where conventional microscopy techniques fail. However, while most wavefront-shaping works to-date exploited direct access to the target or implanted probes, the challenge is to apply it non-invasively inside complex samples. Ultrasonic-tagging techniques have been recently demonstrated but these require a sequential point-by- point acquisition, a major drawback for imaging applications. Here, we introduce a novel approach to non-invasively measure the optical transmission-matrix inside a scattering medium, exploiting the photo-acoustic effect. Our approach allows for the first time to simultaneously discriminate, localize, and selectively focus light on multiple targets inside a scattering sample, as well as to recover and exploit the scattering medium properties. Combining the powerful approach of the transmission-matrix with the advantages of photoacoustic imaging opens the path towards deep-tissue imaging and light-delivery utilizing endogenous optical contrast.

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T. Chaigne, O. Katz, A. C. Boccara, M. Fink, E. Bossy, S. Gigan. 2013-05-27. Controlling light in scattering media noninvasively using the photo-acoustic transmission-matrix. https://doi.org/10.1038/nphoton.2013.307

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