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arXiv · 1306.1264

The Chills and Thrills of Whole Genome Sequencing

Erman Ayday·Emiliano De Cristofaro·Jean-Pierre Hubaux·Gene Tsudik
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Abstract

In recent years, Whole Genome Sequencing (WGS) evolved from a futuristic-sounding research project to an increasingly affordable technology for determining complete genome sequences of complex organisms, including humans. This prompts a wide range of revolutionary applications, as WGS promises to improve modern healthcare and provide a better understanding of the human genome -- in particular, its relation to diseases and response to treatments. However, this progress raises worrisome privacy and ethical issues, since, besides uniquely identifying its owner, the genome contains a treasure trove of highly personal and sensitive information. In this article, after summarizing recent advances in genomics, we discuss some important privacy issues associated with human genomic information and identify a number of particularly relevant research challenges.

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Erman Ayday, Emiliano De Cristofaro, Jean-Pierre Hubaux, Gene Tsudik. 2013-06-05. The Chills and Thrills of Whole Genome Sequencing. https://arxiv.org/abs/1306.1264

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