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arXiv · 1309.5078

A filter-flow perspective of hematogenous metastasis offers a non-genetic paradigm for personalized cancer therapy

Jacob G. Scott·Alexander G. Fletcher·Philip K. Maini·Alexander R. A. Anderson·Philip Gerlee
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Abstract

Research into mechanisms of hematogenous metastasis has largely become genetic in focus, attempting to understand the molecular basis of `seed-soil' relationships. Preceeding this biological mechanism is the physical process of dissemination of circulating tumour cells (CTCs). We utilize a `filter-flow' paradigm to show that assumptions about CTC dynamics strongly affect metastatic efficiency: without data on CTC dynamics, any attempt to predict metastatic spread in individual patients is impossible.

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Jacob G. Scott, Alexander G. Fletcher, Philip K. Maini, Alexander R. A. Anderson, Philip Gerlee. 2013-09-19. A filter-flow perspective of hematogenous metastasis offers a non-genetic paradigm for personalized cancer therapy. https://arxiv.org/abs/1309.5078

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