Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm

Anita Mehta; Jean-Marc Luck; Collin C. Luk; Naweed I. Syed

doi:10.1371/journal.pone.0078056

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arXiv · 1310.0218

Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm

Anita Mehta·Jean-Marc Luck·Collin C. Luk·Naweed I. Syed

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Abstract

We present a mathematical model which explains and interprets a novel form of short-term potentiation, which was found to be use-, but not time-dependent, in experiments done on Lymnaea neurons. The high degree of potentiation is explained using a model of synaptic metaplasticity, while the use-dependence (which is critically reliant on the presence of kinase in the experiment) is explained using a model of a stochastic and bistable biological switch.

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Anita Mehta, Jean-Marc Luck, Collin C. Luk, Naweed I. Syed. 2013-10-01. Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm. https://doi.org/10.1371/journal.pone.0078056

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