Lattice solution model for order-disorder transitions in membranes and Langmuir monolayers

Abstract

Lipid monolayers and bilayers have been used as experimental models for the investigation of membrane thermal transitions. The main transition takes place near ambient temperatures for several lipids and reflects the order-disorder transition of lipid hydrocarbonic chains, which is accompanied by a small density gap. Equivalence between the transitions in the two systems has been argued by several authors. The two-state statistical model adopted by numerous authors for different properties of the membrane, such as permeability, diffusion, mixture or insertion of cholesterol or protein, is inadequate for the description of charged membranes, since it lacks a proper description of surface density. We propose a lattice solution model which adds interactions with water molecules to lipid-lipid interactions and obtain its thermal properties under a mean-field approach. Density variations, although concomitant with chain order variations, are independent of the latter. The model presents both chain order and gas-liquid transitions, and extends the range of applicability of previous models, yielding Langmuir isotherms in the full range of pressures and areas.