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arXiv · 1311.7650

Adaptive nonparametric detection in cryo-electron microscopy

Mikhail Langovoy·Michael Habeck·Bernhard Schoelkopf
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Abstract

Cryo-electron microscopy (cryo-EM) is an emerging experimental method to characterize the structure of large biomolecular assemblies. Single particle cryo-EM records 2D images (so-called micrographs) of projections of the three-dimensional particle, which need to be processed to obtain the three-dimensional reconstruction. A crucial step in the reconstruction process is particle picking which involves detection of particles in noisy 2D micrographs with low signal-to-noise ratios of typically 1:10 or even lower. Typically, each picture contains a large number of particles, and particles have unknown irregular and nonconvex shapes.

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Mikhail Langovoy, Michael Habeck, Bernhard Schoelkopf. 2013-11-29. Adaptive nonparametric detection in cryo-electron microscopy. https://arxiv.org/abs/1311.7650

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