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arXiv · 1312.4902

Dynamic DNA Processing: A Microcode Model of Cell Differentiation

Barry D. Jacobson
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Abstract

A general theoretical framework is put forth to organize and understand various observed phenomena and mathematical relationships in the field of molecular biology. By modeling each cell in eukaryotic organisms as a processor having a unique set of allowed states, represented by a specific DNA sequence, we demonstrate a method by which gene expression can be regulated. As the theory is developed, we suggest reasons for the complementary, quaternary (4-base) coding scheme used in most eukaryotes. A role for transposable elements is suggested, as is a role for the abundance of noncoding DNA, along with a clearly-defined method by which single nucleotide polymorphisms (SNP's) may alter gene expression. The effect of various errors is considered. Finally, a mechanism for inter-processor communication is proposed to explain cell-cell recognition processes, which leads to an elucidation of a possible pathway by which nonmutagenic carcinogenic agents may act.

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Barry D. Jacobson. 2013-12-17. Dynamic DNA Processing: A Microcode Model of Cell Differentiation. https://arxiv.org/abs/1312.4902

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