Prediction and Dissipation in Biochemical Sensing

Nils B. Becker; Andrew Mugler; Pieter Rein ten Wolde

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arXiv · 1312.5625

Prediction and Dissipation in Biochemical Sensing

Nils B. Becker·Andrew Mugler·Pieter Rein ten Wolde

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Abstract

Cells sense and predict their environment via energy-dissipating pathways. However, it is unclear whether dissipation helps or harms prediction. Here we study dissipation and prediction for a minimal sensory module of receptors that reversibly bind ligand. We find that the module performs short-term prediction optimally when operating in an adiabatic regime where dissipation vanishes. In contrast, beyond a critical forecast interval, prediction becomes most precise in a regime of maximal dissipation, suggesting that dissipative sensing in biological systems can serve to enhance prediction performance.

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Nils B. Becker, Andrew Mugler, Pieter Rein ten Wolde. 2013-12-19. Prediction and Dissipation in Biochemical Sensing. https://arxiv.org/abs/1312.5625

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