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arXiv · 1404.1430

Counterion Effects on Nano-confined Metal-Drug-DNA Complexes

Nupur Biswas·Sreeja Chakraborty·Alokmay Datta·Munna Sarkar·Mrinmay K. Mukhopadhyay·Mrinal K. Bera·Hideki Seto
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Abstract

We have explored morphology of DNA molecules bound with Cu-complexes of piroxicam molecules, a non-steroidal anti-inflammatory drug (NSAID), under one-dimensional confinement of thin films and have studied the effect of counterions present in a buffer. X-ray reflectivity at and away from the Cu K absorption edge and atomic force microscopy studies reveal that confinement segregates the drug molecules preferentially in a top layer of the DNA film, and counterions enhance this segregation.

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Nupur Biswas, Sreeja Chakraborty, Alokmay Datta, Munna Sarkar, Mrinmay K. Mukhopadhyay, Mrinal K. Bera, Hideki Seto. 2016-01-21. Counterion Effects on Nano-confined Metal-Drug-DNA Complexes. https://doi.org/10.3762/bjnano.7.7

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