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arXiv · 1501.02409

Surface modified sulfur nanoparticles can escape the glutathione reductase mediated detoxification system in fungi

Samrat Roy Choudhury·Arunava Goswami
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Abstract

The antifungal effects of orthorhombic (~10 nm; spherical) and monoclinic (~50 nm; tetrapod) sulfur nanoparticles (SNPs) were studied against the NADPH-dependent glutathione reductase (GR) mediated xenobiotic detoxification system (GSH-GSSG) in filamentous fungi (Aspergillus niger as a model organism). Both the SNPs induced significant reduction in fungal growth and spore formation, and also introduced marked deformities on the surface of conidiophores at their sub-inhibitory concentrations. A genome wide transcriptome profile then revealed manifold reduction in the expression of GSH-GSSG transcripts among SNPs treated fungal isolates, which is unusual for the micron sized elemental sulfur but probably effective in terms of antifungal efficacy.

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Samrat Roy Choudhury, Arunava Goswami. 2015-01-11. Surface modified sulfur nanoparticles can escape the glutathione reductase mediated detoxification system in fungi. https://arxiv.org/abs/1501.02409

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