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arXiv · 1501.04443

Spatial Moran models I. Stochastic tunneling in the neutral case

Richard Durrett·Stephen Moseley
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Abstract

We consider a multistage cancer model in which cells are arranged in a $d$-dimensional integer lattice. Starting with all wild-type cells, we prove results about the distribution of the first time when two neutral mutations have accumulated in some cell in dimensions $d\ge 2$, extending work done by Komarova [Genetics 166 (2004) 1571-1579] for $d=1$.

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Richard Durrett, Stephen Moseley. 2015-01-19. Spatial Moran models I. Stochastic tunneling in the neutral case. https://doi.org/10.1214/13-aap989

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